{"id":25042,"date":"2026-04-02T07:00:00","date_gmt":"2026-04-02T07:00:00","guid":{"rendered":"https:\/\/cellura.io\/cellura-au-pscc-ecosystem-breakfast-surmonter-la-variabilite-des-organoides-tumoraux-grace-a-softxs\/"},"modified":"2026-07-23T10:55:15","modified_gmt":"2026-07-23T10:55:15","slug":"cellura-au-pscc-ecosystem-breakfast-surmonter-la-variabilite-des-organoides-tumoraux-grace-a-softxs","status":"publish","type":"post","link":"https:\/\/cellura.io\/fr\/cellura-au-pscc-ecosystem-breakfast-surmonter-la-variabilite-des-organoides-tumoraux-grace-a-softxs\/","title":{"rendered":"Cellura au PSCC Ecosystem Breakfast : surmonter la variabilit\u00e9 des organo\u00efdes tumoraux gr\u00e2ce \u00e0 SoftXS\u2122"},"content":{"rendered":"\t\t
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Cellura participera au prochain PSCC Ecosystem Breakfast<\/strong> \u00e0 Paris-Saclay, o\u00f9 Benjamin Saulnier, CEO de Cellura<\/strong>, pr\u00e9sentera SoftXS\u2122, une technologie de rupture con\u00e7ue pour relever l\u2019un des principaux d\u00e9fis de la recherche en oncologie : la standardisation et le passage \u00e0 l\u2019\u00e9chelle des organo\u00efdes tumoraux.<\/strong><\/p>

Les organo\u00efdes tumoraux sont devenus des outils essentiels pour reproduire la complexit\u00e9 biologique des tumeurs humaines. Ils permettent de mod\u00e9liser avec une plus grande fid\u00e9lit\u00e9 l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 tumorale, les interactions cellulaires et les r\u00e9ponses aux traitements. Cependant, leur transition du mod\u00e8le de recherche vers des plateformes translationnelles et industrielles demeure encore limit\u00e9e par des contraintes technologiques. <\/p>

Le principal enjeu n\u2019est pas le potentiel biologique, mais la ma\u00eetrise des param\u00e8tres m\u00e9caniques. <\/p>

La limite cach\u00e9e des cultures cellulaires 3D conventionnelles<\/strong><\/h5>

Les syst\u00e8mes conventionnels de culture 3D reposent sur une agitation assur\u00e9e par des h\u00e9lices ou par bullage. Lorsque le volume de culture augmente, les contraintes m\u00e9caniques s\u2019intensifient consid\u00e9rablement. Cela entra\u00eene : <\/p>

\u2022 Une augmentation des contraintes de cisaillement
\u2022 Des gradients h\u00e9t\u00e9rog\u00e8nes en oxyg\u00e8ne et en nutriments
\u2022 Une variabilit\u00e9 d\u2019un lot \u00e0 l\u2019autre
\u2022 Une diminution de la reproductibilit\u00e9<\/p>

Pour des syst\u00e8mes fragiles tels que les organo\u00efdes tumoraux, ces contraintes m\u00e9caniques peuvent alt\u00e9rer leur viabilit\u00e9, leur morphologie ainsi que leurs caract\u00e9ristiques fonctionnelles. Elles limitent ainsi leur fiabilit\u00e9 pour le criblage th\u00e9rapeutique et freinent leur d\u00e9ploiement \u00e0 l’\u00e9chelle industrielle. <\/p>

SoftXS\u2122 : une innovation pour le contr\u00f4le des contraintes de cisaillement<\/strong><\/h5>

Lors de la session du PSCC, Benjamin Saulnier pr\u00e9sentera SoftXS\u2122<\/strong>, la plateforme de bior\u00e9acteur 3D \u00e0 faibles contraintes de cisaillement d\u00e9velopp\u00e9e par Cellura.<\/p>

SoftXS\u2122 introduit un syst\u00e8me de m\u00e9lange sans pales, inspir\u00e9 de principes g\u00e9om\u00e9triques, qui g\u00e9n\u00e8re un \u00e9coulement chaotique contr\u00f4l\u00e9 sans recourir \u00e0 des h\u00e9lices. Au lieu d\u2019augmenter les contraintes de cisaillement lors du passage \u00e0 l\u2019\u00e9chelle, ce syst\u00e8me permet de maintenir : <\/p>

\u2022 Une suspension homog\u00e8ne des cellules et des organo\u00efdes
\u2022 Un contr\u00f4le pr\u00e9cis des contraintes m\u00e9caniques
\u2022 Une r\u00e9duction des contraintes de cisaillement
\u2022 Des conditions hydrodynamiques stables<\/p>

De r\u00e9centes \u00e9tudes men\u00e9es en suspension ont d\u00e9montr\u00e9 qu\u2019une remise en suspension homog\u00e8ne peut \u00eatre obtenue \u00e0 des vitesses de rotation comprises entre 30 et 60 tr\/min, avec des niveaux de contraintes de cisaillement 12 \u00e0 50 fois inf\u00e9rieurs \u00e0 ceux observ\u00e9s dans les bior\u00e9acteurs conventionnels<\/strong>.<\/p>

Il ne s\u2019agit pas d\u2019une am\u00e9lioration marginale, mais d\u2019un changement fondamental dans la mani\u00e8re de concevoir et de mettre en \u0153uvre les cultures cellulaires 3D. <\/p>

Du mod\u00e8le de laboratoire \u00e0 une plateforme \u00e9volutive<\/strong><\/h5>

La pr\u00e9sentation mettra en lumi\u00e8re les principaux param\u00e8tres permettant d\u2019assurer une v\u00e9ritable standardisation :<\/p>

\u2022 L\u2019optimisation du rapport d\u2019aspect
\u2022 Le contr\u00f4le de l\u2019angle d\u2019inclinaison
\u2022 La d\u00e9termination de la vitesse critique de mise en suspension
\u2022 Le contr\u00f4le des conditions de r\u00e9sonance hydrodynamique
\u2022 Le passage \u00e0 l\u2019\u00e9chelle sans modification de la conception du syst\u00e8me<\/p>

Contrairement aux syst\u00e8mes conventionnels \u00e0 cuve agit\u00e9e, pour lesquels le passage \u00e0 l\u2019\u00e9chelle n\u00e9cessite une r\u00e9ing\u00e9nierie du proc\u00e9d\u00e9, SoftXS\u2122 conserve des principes de fonctionnement identiques, depuis l\u2019\u00e9chelle du laboratoire jusqu\u2019\u00e0 des volumes repr\u00e9sentatifs d\u2019une production industrielle.<\/p>

Cela permet aux organo\u00efdes tumoraux de d\u00e9passer le stade de la simple faisabilit\u00e9 exp\u00e9rimentale pour \u00e9voluer vers une production reproductible, standardis\u00e9e et \u00e9volutive.<\/p>

Des fondements scientifiques valid\u00e9s<\/strong><\/h5>

L\u2019approche technologique d\u00e9velopp\u00e9e par Cellura repose sur une validation scientifique r\u00e9alis\u00e9e par des experts reconnus en h\u00e9matologie et en th\u00e9rapie cellulaire, notamment par les \u00e9quipes dirig\u00e9es par Anne-Lise Bennaceur-Griscelli<\/strong> et Ali Turhan.<\/p>

Ces validations confirment la compatibilit\u00e9 de la technologie avec des syst\u00e8mes cellulaires fragiles, notamment les cellules souches pluripotentes induites (iPSC), les cellules immunitaires et les organo\u00efdes.<\/p>

Un objectif strat\u00e9gique pour l\u2019oncologie<\/strong><\/h5>

L\u2019objectif de cette session du PSCC est clair :<\/p>

Gr\u00e2ce \u00e0 sa technologie de contr\u00f4le des contraintes de cisaillement, SoftXS\u2122 transforme les organo\u00efdes tumoraux en une plateforme standardis\u00e9e, robuste et industrialisable<\/strong>, capable d\u2019acc\u00e9l\u00e9rer le criblage th\u00e9rapeutique, la m\u00e9decine personnalis\u00e9e et le d\u00e9veloppement de nouvelles approches en oncologie.<\/p>

En participant au PSCC Ecosystem Breakfast, Cellura souhaite contribuer \u00e0 l\u2019\u00e9volution strat\u00e9gique des technologies d\u2019organo\u00efdes au sein de l\u2019\u00e9cosyst\u00e8me d\u2019oncologie de Paris-Saclay.<\/p>

SoftXS\u2122 n\u2019est pas seulement un bior\u00e9acteur. Il constitue un nouveau cadre m\u00e9canique con\u00e7u pour r\u00e9v\u00e9ler tout le potentiel translationnel des mod\u00e8les tumoraux 3D complexes. <\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/article><\/div>

\u00c0 propos de l’\u00e9v\u00e9nement<\/strong><\/h5>

Vous trouverez plus d\u2019informations sur le PSCC Ecosystem Breakfast sur la page officielle de l\u2019\u00e9v\u00e9nement : https:\/\/www.parissaclaycancercluster.org\/news-du-pscc\/categories\/replay-petit-dej<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Cellura participera au prochain PSCC Ecosystem Breakfast \u00e0 Paris-Saclay, o\u00f9 Benjamin Saulnier, CEO de Cellura, pr\u00e9sentera SoftXS\u2122, une technologie de rupture con\u00e7ue pour relever l\u2019un des principaux d\u00e9fis de la…<\/p>\n","protected":false},"author":2,"featured_media":24611,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[221],"tags":[705,226,1090,929,926,317,937,933,889,945,936,932,1101,931,943,944,352,975,941,934,580,581,930,976,927,1099,935,291],"class_list":["post-25042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evenement-congres","tag-benjamin-saulnier","tag-bioproduction","tag-bioproduction-a-grande-echelle","tag-biotechnologie","tag-cellules-souches","tag-cellura","tag-collaboration-entre-le-monde-universitaire-et-le-secteur-prive","tag-culture-cellulaire-douce","tag-culture-cellulaire-en-3d","tag-de-la-recherche-a-lindustrie","tag-ecosysteme-de-linnovation","tag-innovation-en-matiere-de-cancer","tag-innovation-en-oncologie","tag-modeles-cellulaires-avances","tag-modeles-cellulaires-fragiles","tag-oncologie-translationnelle","tag-organoides","tag-organoides-tumoraux","tag-pole-de-recherche-sur-le-cancer-de-paris-saclay","tag-production-cellulaire-evolutive","tag-pscc","tag-pscc-paris-saclay","tag-recherche-en-oncologie","tag-recherche-sur-le-cancer","tag-sciences-de-la-vie","tag-standardisation-des-organoides","tag-technologies-de-mise-a-lechelle","tag-therapie-cellulaire"],"yoast_head":"\nCellura 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